Assay Detail
Binding
CHEMBL3782136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant MTH1 (unknown origin) assessed as hydrolysis of 8-oxodGTP to 8-oxodGMP and pyrophosphate by PPiLight assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Oxidized purine nucleoside triphosphate hydrolase (CHEMBL3708265) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of potent and selective MTH1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.00 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3780962 | — | — | 1 | 9.70 |
| CHEMBL3781661 | — | — | 1 | 9.70 |
| CHEMBL3780613 | — | — | 1 | 9.30 |
| CHEMBL3780596 | — | — | 1 | 9.30 |
| CHEMBL3780032 | — | — | 1 | 9.22 |
| CHEMBL3781316 | — | — | 1 | 8.80 |
| CHEMBL3780321 | — | — | 1 | 8.74 |
| CHEMBL3781917 | — | — | 1 | 8.51 |
| CHEMBL3781015 | — | — | 1 | 8.35 |
| CHEMBL3782004 | — | — | 1 | 8.00 |
| CHEMBL3780307 | — | — | 1 | 8.00 |
| CHEMBL3781296 | — | — | 1 | 7.66 |
| CHEMBL3781387 | — | — | 1 | 7.28 |
| CHEMBL3781861 | — | — | 1 | 7.08 |
| CHEMBL3781493 | — | — | 1 | 6.95 |
| CHEMBL3781662 | — | — | 1 | 6.92 |
| CHEMBL3780652 | — | — | 1 | 6.52 |
| CHEMBL3781282 | — | — | 1 | 6.48 |
| CHEMBL3781267 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3780962 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3781661 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3780613 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3780596 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL3780032 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3781316 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3780321 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL3781917 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL3781015 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3782004 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3780307 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3781296 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3781387 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3781861 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL3781493 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL3781662 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3780652 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL3781282 | — | IC50 | = | 332.0 | nM | 6.48 |
| CHEMBL3781267 | — | IC50 | = | 2980.0 | nM | 5.53 |