Assay Detail
Binding
CHEMBL3782444
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Inhibition of telomerase in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MGC-803 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of human telomerase inhibitors having the core of N-acyl-4,5-dihydropyrazole with anticancer effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.18 | 5.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3780654 | — | — | 1 | 5.73 |
| CHEMBL284328 | HOMIDIUM BROMIDE | 2.0 | 1 | 5.66 |
| CHEMBL3782024 | — | — | 1 | 5.40 |
| CHEMBL3781107 | — | — | 1 | 4.60 |
| CHEMBL3781523 | — | — | 1 | 4.53 |
| CHEMBL3780707 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3780654 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL284328 | HOMIDIUM BROMIDE | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL3782024 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3781107 | — | IC50 | = | 24950.0 | nM | 4.60 |
| CHEMBL3781523 | — | IC50 | = | 29810.0 | nM | 4.53 |
| CHEMBL3780707 | — | IC50 | > | 60000.0 | nM | - |