Assay Detail
Binding
CHEMBL3783010
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against human NK1 receptor expressed in CHO-K1 cells by aequorin luminescence assay based Schild's plot analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.13 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3408519 | — | — | 1 | 8.19 |
| CHEMBL3780686 | — | — | 1 | 8.17 |
| CHEMBL3781336 | — | — | 1 | 8.12 |
| CHEMBL1782141 | — | — | 1 | 8.11 |
| CHEMBL3781519 | — | — | 1 | 8.09 |
| CHEMBL3780818 | — | — | 1 | 8.08 |
| CHEMBL3780776 | — | — | 1 | - |
| CHEMBL3780820 | — | — | 1 | - |
| CHEMBL3780408 | — | — | 1 | - |
| CHEMBL3781680 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3408519 | — | Ki | = | 6.44 | nM | 8.19 |
| CHEMBL3780686 | — | Ki | = | 6.72 | nM | 8.17 |
| CHEMBL3781336 | — | Ki | = | 7.54 | nM | 8.12 |
| CHEMBL1782141 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL3781519 | — | Ki | = | 8.11 | nM | 8.09 |
| CHEMBL3780818 | — | Ki | = | 8.33 | nM | 8.08 |
| CHEMBL3780776 | — | Ki | - | — | - | |
| CHEMBL3780820 | — | Ki | - | — | - | |
| CHEMBL3780408 | — | Ki | - | — | - | |
| CHEMBL3781680 | — | Ki | - | — | - |