Assay Detail
Binding
CHEMBL3783186
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HCK (unknown origin) preincubated for 2 hrs followed by FRET peptide addition measured after 1 hr by Z-LYTE assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Narrow Spectrum Kinase Inhibitors: New Therapeutic Agents for the Treatment of COPD and Steroid-Resistant Asthma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.30 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3781532 | — | — | 1 | 7.58 |
| CHEMBL3781687 | — | — | 1 | 7.58 |
| CHEMBL3781102 | — | — | 1 | 7.29 |
| CHEMBL3695568 | JNJ-49095397 | 2.0 | 1 | 7.28 |
| CHEMBL3781430 | — | — | 1 | 7.09 |
| CHEMBL3780832 | — | — | 1 | 6.96 |
| CHEMBL3780154 | — | — | 1 | 6.79 |
| CHEMBL3780667 | — | — | 1 | 6.73 |
| CHEMBL3781244 | — | — | 1 | 6.71 |
| CHEMBL3781245 | — | — | 1 | 6.68 |
| CHEMBL3780488 | — | — | 1 | 6.32 |
| CHEMBL3780111 | — | — | 1 | 6.20 |
| CHEMBL3781473 | — | — | 1 | 6.16 |
| CHEMBL3781982 | — | — | 1 | 6.09 |
| CHEMBL3781587 | — | — | 1 | 6.08 |
| CHEMBL143134 | — | — | 1 | 6.04 |
| CHEMBL3782036 | — | — | 1 | 5.95 |
| CHEMBL3780714 | — | — | 1 | 5.67 |
| CHEMBL3782009 | — | — | 1 | 5.49 |
| CHEMBL336001 | — | — | 1 | 5.31 |
| CHEMBL3781999 | — | — | 1 | 5.07 |
| CHEMBL3780386 | — | — | 1 | 5.06 |
| CHEMBL3780519 | — | — | 1 | 4.88 |
| CHEMBL3781413 | — | — | 1 | - |
| CHEMBL3780410 | — | — | 1 | - |
| CHEMBL3780629 | — | — | 1 | - |
| CHEMBL3780089 | — | — | 1 | - |
| CHEMBL343227 | — | — | 1 | - |
| CHEMBL3781528 | — | — | 1 | - |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3781532 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3781687 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL3781102 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3695568 | JNJ-49095397 | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3781430 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL3780832 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3780154 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL3780667 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL3781244 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL3781245 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL3780488 | — | IC50 | = | 482.0 | nM | 6.32 |
| CHEMBL3780111 | — | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL3781473 | — | IC50 | = | 692.0 | nM | 6.16 |
| CHEMBL3781982 | — | IC50 | = | 807.0 | nM | 6.09 |
| CHEMBL3781587 | — | IC50 | = | 829.0 | nM | 6.08 |
| CHEMBL143134 | — | IC50 | = | 901.0 | nM | 6.04 |
| CHEMBL3782036 | — | IC50 | = | 1117.0 | nM | 5.95 |
| CHEMBL3780714 | — | IC50 | = | 2141.0 | nM | 5.67 |
| CHEMBL3782009 | — | IC50 | = | 3221.0 | nM | 5.49 |
| CHEMBL336001 | — | IC50 | = | 4937.0 | nM | 5.31 |
| CHEMBL3781999 | — | IC50 | = | 8552.0 | nM | 5.07 |
| CHEMBL3780386 | — | IC50 | = | 8673.0 | nM | 5.06 |
| CHEMBL3780519 | — | IC50 | = | 13291.0 | nM | 4.88 |
| CHEMBL3781413 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL3780410 | — | IC50 | > | 16000.0 | nM | - |
| CHEMBL3780629 | — | IC50 | > | 16000.0 | nM | - |
| CHEMBL3780089 | — | IC50 | > | 17000.0 | nM | - |
| CHEMBL343227 | — | IC50 | > | 19000.0 | nM | - |
| CHEMBL3781528 | — | IC50 | > | 19000.0 | nM | - |
| CHEMBL103667 | DORAMAPIMOD | IC50 | > | 19000.0 | nM | - |