Assay Detail
Binding
CHEMBL3783233
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of P-gp-mediated resistance to adriamycin in human K562/A02 cells assessed as reduction in adriamycin IC50 after 48 hrs by MTT assay
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | K562/A02 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of LBM-A5 derivatives as potent P-glycoprotein-mediated multidrug resistance inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.52 | 6.71 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3780264 | — | — | 2 | 6.71 |
| CHEMBL3779944 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3780264 | — | EC50 | = | 192.6 | nM | 6.71 |
| CHEMBL3779944 | — | EC50 | = | 483.6 | nM | 6.32 |
| CHEMBL3780264 | — | Activity | - | — | - |