Assay Detail
Functional
CHEMBL3783262
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Cytotoxicity against human HepG2 cells assessed as growth inhibition after 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of hybrid 4-deoxypodophyllotoxin-5-fluorouracil compounds that inhibit cellular migration and induce cell cycle arrest.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.90 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3780449 | — | — | 1 | 6.35 |
| CHEMBL3781120 | — | — | 1 | 4.94 |
| CHEMBL3781218 | — | — | 1 | 4.93 |
| CHEMBL3781256 | — | — | 1 | 4.84 |
| CHEMBL89905 | 4'-DEMETHYLDEOXYPODOPHYLLOTOXIN | — | 1 | 4.78 |
| CHEMBL3779943 | — | — | 1 | 4.70 |
| CHEMBL3781368 | — | — | 1 | 4.65 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 4.57 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.38 |
| CHEMBL3780002 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3780449 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3781120 | — | IC50 | = | 11520.0 | nM | 4.94 |
| CHEMBL3781218 | — | IC50 | = | 11740.0 | nM | 4.93 |
| CHEMBL3781256 | — | IC50 | = | 14330.0 | nM | 4.84 |
| CHEMBL89905 | 4'-DEMETHYLDEOXYPODOPHYLLOTOXIN | IC50 | = | 16530.0 | nM | 4.78 |
| CHEMBL3779943 | — | IC50 | = | 20180.0 | nM | 4.70 |
| CHEMBL3781368 | — | IC50 | = | 22280.0 | nM | 4.65 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 27070.0 | nM | 4.57 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 41620.0 | nM | 4.38 |
| CHEMBL3780002 | — | IC50 | > | 100000.0 | nM | - |