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Assay Detail

CHEMBL3783538

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human MRC5 cells assessed as cell viability after 4 to 7 days by Alamar Blue staining based fluorometric analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type MRC5
Confidence 1 — Organism
Curated By Autocuration

Target

MRC5 (CHEMBL614181)
Type CELL-LINE
Organism Homo sapiens

Publication

In vitro screening of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives as antiprotozoal agents and docking studies on Trypanosoma cruzi CYP51.
De Vita D, Moraca F, Zamperini C, Pandolfi F, Di Santo R, Matheeussen A, Maes L, Tortorella S, Scipione L.
Eur J Med Chem (2016) 113 : 28 -33
PubMed 26922226 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.96 5.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1946740 1 5.14
CHEMBL3781446 1 5.11
CHEMBL1946739 1 5.11
CHEMBL3781420 1 5.10
CHEMBL3781870 1 5.09
CHEMBL3781877 1 5.09
CHEMBL3291243 1 5.09
CHEMBL3780620 1 5.07
CHEMBL3780946 1 5.06
CHEMBL3780605 1 5.06
CHEMBL3781706 1 5.06
CHEMBL83 TAMOXIFEN 4.0 1 4.96
CHEMBL3291242 1 4.81
CHEMBL3291250 1 4.58
CHEMBL3780533 1 4.58
CHEMBL3780260 1 4.43
CHEMBL3291241 1 -
CHEMBL3780819 1 -
CHEMBL3291249 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1946740 IC50 = 7200.0 nM 5.14
CHEMBL3781446 IC50 = 7800.0 nM 5.11
CHEMBL1946739 IC50 = 7800.0 nM 5.11
CHEMBL3781420 IC50 = 8000.0 nM 5.10
CHEMBL3781870 IC50 = 8200.0 nM 5.09
CHEMBL3781877 IC50 = 8200.0 nM 5.09
CHEMBL3291243 IC50 = 8200.0 nM 5.09
CHEMBL3780620 IC50 = 8500.0 nM 5.07
CHEMBL3780946 IC50 = 8700.0 nM 5.06
CHEMBL3780605 IC50 = 8800.0 nM 5.06
CHEMBL3781706 IC50 = 8700.0 nM 5.06
CHEMBL83 TAMOXIFEN IC50 = 10900.0 nM 4.96
CHEMBL3291242 IC50 = 15500.0 nM 4.81
CHEMBL3291250 IC50 = 26400.0 nM 4.58
CHEMBL3780533 IC50 = 26500.0 nM 4.58
CHEMBL3780260 IC50 = 37500.0 nM 4.43
CHEMBL3291241 IC50 > 64000.0 nM -
CHEMBL3780819 IC50 > 64000.0 nM -
CHEMBL3291249 IC50 > 64000.0 nM -