Assay Detail

CHEMBL3783585

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Binding

Inhibition of RSK2 in rabbit skeletal muscle using KKRNRTLSVA as substrate after 10 mins in presence of [gamma32P]ATP

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Oryctolagus cuniculus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Isoindole-1,3-dione derivatives as RSK2 inhibitors: synthesis, molecular docking simulation and SAR analysis

Zhou W, Li S, Lu W, Yuan J, Xu Y, Li H, Huang J, Zhao Z
Medchemcomm (2016) 7 : 292 -296
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.91	8.52

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL6291	BISINDOLYLMALEIMIDE IX	—	1	8.52
CHEMBL7463	GF-109203	—	1	7.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL6291	BISINDOLYLMALEIMIDE IX	IC50	=	3.0	nM	8.52
CHEMBL7463	GF-109203	IC50	=	50.0	nM	7.30