Assay Detail
ADMET
CHEMBL3783676
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Cytotoxicity against human K562 cells assessed as cell viability after 48 hrs by MTT assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of LBM-A5 derivatives as potent P-glycoprotein-mediated multidrug resistance inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.55 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 5.21 |
| CHEMBL247473 | — | — | 1 | 4.71 |
| CHEMBL3781670 | — | — | 1 | 4.68 |
| CHEMBL3780540 | — | — | 1 | 4.55 |
| CHEMBL3781016 | — | — | 1 | 4.43 |
| CHEMBL3781491 | — | — | 1 | 4.31 |
| CHEMBL3780517 | — | — | 1 | 4.31 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 4.18 |
| CHEMBL3780589 | — | — | 1 | - |
| CHEMBL3781586 | — | — | 1 | - |
| CHEMBL3780970 | — | — | 1 | - |
| CHEMBL3780604 | — | — | 1 | - |
| CHEMBL3780770 | — | — | 1 | - |
| CHEMBL3781709 | — | — | 1 | - |
| CHEMBL3780682 | — | — | 1 | - |
| CHEMBL3780244 | — | — | 1 | - |
| CHEMBL3781017 | — | — | 1 | - |
| CHEMBL3781169 | — | — | 1 | - |
| CHEMBL3780913 | — | — | 1 | - |
| CHEMBL3780498 | — | — | 1 | - |
| CHEMBL3781382 | — | — | 1 | - |
| CHEMBL3780045 | — | — | 1 | - |
| CHEMBL3780609 | — | — | 1 | - |
| CHEMBL3780264 | — | — | 1 | - |
| CHEMBL3780081 | — | — | 1 | - |
| CHEMBL3780821 | — | — | 1 | - |
| CHEMBL3779944 | — | — | 1 | - |
| CHEMBL3781398 | — | — | 1 | - |
| CHEMBL3781228 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 6230.0 | nM | 5.21 |
| CHEMBL247473 | — | IC50 | = | 19560.0 | nM | 4.71 |
| CHEMBL3781670 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL3780540 | — | IC50 | = | 28020.0 | nM | 4.55 |
| CHEMBL3781016 | — | IC50 | = | 37400.0 | nM | 4.43 |
| CHEMBL3781491 | — | IC50 | = | 48770.0 | nM | 4.31 |
| CHEMBL3780517 | — | IC50 | = | 49220.0 | nM | 4.31 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 65280.0 | nM | 4.18 |
| CHEMBL3780589 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3781586 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3780970 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3780604 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3780770 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3781709 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3780682 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3780244 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3781017 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3781169 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3780913 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3780498 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3781382 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3780045 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3780609 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3780264 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3780081 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3780821 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3779944 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3781398 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3781228 | — | IC50 | > | 100000.0 | nM | - |