Assay Detail
Binding
CHEMBL3784057
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Inhibition of recombinant human MAO-A using p-tyramine as substrate assessed as H2O2 production preincubated for 15 mins followed by substrate addition measured for 15 mins by amplex red assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Monoamine Oxidase Inhibitory Activity of Novel Pyrazoline Analogues: Curcumin Based Design and Synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.89 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3780199 | — | — | 1 | 7.22 |
| CHEMBL86304 | MOCLOBEMIDE | 4.0 | 1 | 6.96 |
| CHEMBL3780346 | — | — | 1 | 6.54 |
| CHEMBL3780057 | — | — | 1 | 6.36 |
| CHEMBL3780858 | — | — | 1 | 6.26 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 6.15 |
| CHEMBL3781033 | — | — | 1 | 5.67 |
| CHEMBL3781838 | — | — | 1 | 5.59 |
| CHEMBL3780319 | — | — | 1 | 5.41 |
| CHEMBL3781258 | — | — | 1 | 5.37 |
| CHEMBL3780212 | — | — | 1 | 5.30 |
| CHEMBL3780097 | — | — | 1 | 5.02 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3780199 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL86304 | MOCLOBEMIDE | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL3780346 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL3780057 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL3780858 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL140 | CURCUMIN | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL3781033 | — | Ki | = | 2160.0 | nM | 5.67 |
| CHEMBL3781838 | — | Ki | = | 2580.0 | nM | 5.59 |
| CHEMBL3780319 | — | Ki | = | 3870.0 | nM | 5.41 |
| CHEMBL3781258 | — | Ki | = | 4250.0 | nM | 5.37 |
| CHEMBL3780212 | — | Ki | = | 5020.0 | nM | 5.30 |
| CHEMBL3780097 | — | Ki | = | 9550.0 | nM | 5.02 |
| CHEMBL972 | SELEGILINE | Ki | = | 16890.0 | nM | 4.77 |