Assay Detail
Binding
CHEMBL3784071
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at Renilla luciferase/GFP2-tagged RXRalpha homodimer (unknown origin) expressed in HEK293T cells by BRET2 assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.63 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3780763 | — | — | 1 | 7.80 |
| CHEMBL3781132 | — | — | 1 | 7.60 |
| CHEMBL1023 | BEXAROTENE | 4.0 | 1 | 7.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3780763 | — | EC50 | = | 15.85 | nM | 7.80 |
| CHEMBL3781132 | — | EC50 | = | 25.12 | nM | 7.60 |
| CHEMBL1023 | BEXAROTENE | EC50 | = | 31.62 | nM | 7.50 |