Assay Detail
Binding
CHEMBL3784104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PRMT1 using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation proximity assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 1 (CHEMBL5524) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.55 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3780926 | — | — | 1 | 4.92 |
| CHEMBL3780444 | — | — | 1 | 4.41 |
| CHEMBL3780701 | — | — | 1 | 4.32 |
| CHEMBL3781841 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3780926 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL3780444 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL3780701 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL3781841 | — | IC50 | > | 1000000.0 | nM | - |