Assay Detail
Functional
CHEMBL3784149
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Inhibition IL-7-indcued STAT5 phosphorylation in rat whole blood by flow cytometry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.13 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3780091 | — | — | 1 | 7.40 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 6.86 |
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3780091 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL1789941 | RUXOLITINIB | IC50 | - | — | - |