Assay Detail
Functional
CHEMBL3784401
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
19
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic Evaluation against Breast Cancer Cells of Isoliquiritigenin Analogues from Spatholobus suberectus and Their Synthetic Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.80 | 8.41 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.41 |
| CHEMBL227779 | — | — | 1 | 5.19 |
| CHEMBL597838 | — | — | 1 | 5.18 |
| CHEMBL3781713 | — | — | 1 | 5.13 |
| CHEMBL36584 | METOCHALCONE | 2.0 | 1 | 5.10 |
| CHEMBL3780469 | — | — | 1 | - |
| CHEMBL338066 | 4,2',4',6'-TETRAHYDROXYCHALCONE | — | 1 | - |
| CHEMBL145927 | 4,4'-DIHYDROXYCHALCONE | — | 1 | - |
| CHEMBL105310 | 2',4'-DIHYDROXYCHALCONE | — | 1 | - |
| CHEMBL2297684 | — | — | 1 | - |
| CHEMBL1774602 | — | — | 1 | - |
| CHEMBL2377597 | — | — | 1 | - |
| CHEMBL32571 | — | — | 1 | - |
| CHEMBL9687 | — | — | 1 | - |
| CHEMBL192877 | DAVIDIGENIN | — | 1 | - |
| CHEMBL45068 | PHLORETIN | — | 1 | - |
| CHEMBL1698547 | — | — | 1 | - |
| CHEMBL3781309 | — | — | 1 | - |
| CHEMBL129795 | ISOLIQUIRITIGENIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL227779 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL597838 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL3781713 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL36584 | METOCHALCONE | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL3780469 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL338066 | 4,2',4',6'-TETRAHYDROXYCHALCONE | IC50 | > | 10000.0 | nM | - |
| CHEMBL145927 | 4,4'-DIHYDROXYCHALCONE | IC50 | > | 10000.0 | nM | - |
| CHEMBL105310 | 2',4'-DIHYDROXYCHALCONE | IC50 | > | 10000.0 | nM | - |
| CHEMBL2297684 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1774602 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2377597 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL32571 | — | Activity | - | — | - | |
| CHEMBL9687 | — | Activity | - | — | - | |
| CHEMBL192877 | DAVIDIGENIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL45068 | PHLORETIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL1698547 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3781309 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL129795 | ISOLIQUIRITIGENIN | IC50 | > | 10000.0 | nM | - |