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Assay Detail

CHEMBL3784756

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PI3Kdelta (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Publication

Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo.
Honda A, Harrington E, Cornella-Taracido I, Furet P, Knapp MS, Glick M, Triantafellow E, Dowdle WE, Wiedershain D, Maniara W, Moore C, Finan PM, Hamann LG, Firestone B, Murphy LO, Keaney EP.
ACS Med Chem Lett (2016) 7 : 72 -76
PubMed 26819669 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.67 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3780339 1 6.30
CHEMBL3781926 1 6.13
CHEMBL3781466 1 6.09
CHEMBL3781415 1 5.92
CHEMBL3780029 1 5.54
CHEMBL3781615 1 5.43
CHEMBL3780762 1 5.38
CHEMBL3781916 1 5.16
CHEMBL3781634 1 5.07
CHEMBL3781020 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3780339 IC50 = 500.0 nM 6.30
CHEMBL3781926 IC50 = 740.0 nM 6.13
CHEMBL3781466 IC50 = 820.0 nM 6.09
CHEMBL3781415 IC50 = 1200.0 nM 5.92
CHEMBL3780029 IC50 = 2900.0 nM 5.54
CHEMBL3781615 IC50 = 3700.0 nM 5.43
CHEMBL3780762 IC50 = 4200.0 nM 5.38
CHEMBL3781916 IC50 = 7000.0 nM 5.16
CHEMBL3781634 IC50 = 8500.0 nM 5.07
CHEMBL3781020 IC50 > 9100.0 nM -