Assay Detail
Binding
CHEMBL3784772
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Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In silico to in vitro screening of hydroxypyridinones as acetylcholinesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.98 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 8.70 |
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | 5.26 |
| CHEMBL2288699 | P-TOLYL DIMETHYLCARBAMATE | — | 1 | - |
| CHEMBL3781763 | — | — | 1 | - |
| CHEMBL3781438 | — | — | 1 | - |
| CHEMBL3780941 | — | — | 1 | - |
| CHEMBL326815 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL2288699 | P-TOLYL DIMETHYLCARBAMATE | IC50 | = | 1282000.0 | nM | - |
| CHEMBL3781763 | — | IC50 | = | 216500.0 | nM | - |
| CHEMBL3781438 | — | IC50 | = | 252300.0 | nM | - |
| CHEMBL3780941 | — | IC50 | = | 347600.0 | nM | - |
| CHEMBL326815 | — | IC50 | = | 219900.0 | nM | - |