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Assay Detail

CHEMBL3787806

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human carbonic anhydrase 2 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 2 (CHEMBL205)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Isatin analogs as novel inhibitors of Candida spp. β-carbonic anhydrase enzymes.
Akdemir A, Güzel-Akdemir Ö, Karalı N, Supuran CT.
Bioorg Med Chem (2016) 24 : 1648 -1652
PubMed 26951893 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 6.44 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL20 ACETAZOLAMIDE 4.0 1 7.92
CHEMBL3785289 1 7.00
CHEMBL3765353 1 6.79
CHEMBL3787255 1 6.63
CHEMBL3785846 1 6.60
CHEMBL3785591 1 6.58
CHEMBL3787472 1 6.51
CHEMBL3786969 1 6.37
CHEMBL3787489 1 6.37
CHEMBL3787222 1 6.34
CHEMBL3785827 1 6.33
CHEMBL3786724 1 6.33
CHEMBL3786477 1 6.32
CHEMBL3785654 1 6.31
CHEMBL3786062 1 6.29
CHEMBL1369708 1 6.28
CHEMBL3785209 1 6.26
CHEMBL3787586 1 6.26
CHEMBL3633555 1 6.25
CHEMBL3785467 1 6.21
CHEMBL3786965 1 6.19
CHEMBL3787148 1 6.17
CHEMBL3785735 1 6.15
CHEMBL3785153 1 6.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL20 ACETAZOLAMIDE Ki = 12.0 nM 7.92
CHEMBL3785289 Ki = 101.0 nM 7.00
CHEMBL3765353 Ki = 164.0 nM 6.79
CHEMBL3787255 Ki = 236.0 nM 6.63
CHEMBL3785846 Ki = 250.0 nM 6.60
CHEMBL3785591 Ki = 264.0 nM 6.58
CHEMBL3787472 Ki = 309.0 nM 6.51
CHEMBL3786969 Ki = 432.0 nM 6.37
CHEMBL3787489 Ki = 428.0 nM 6.37
CHEMBL3787222 Ki = 454.0 nM 6.34
CHEMBL3785827 Ki = 462.0 nM 6.33
CHEMBL3786724 Ki = 468.0 nM 6.33
CHEMBL3786477 Ki = 484.0 nM 6.32
CHEMBL3785654 Ki = 491.0 nM 6.31
CHEMBL3786062 Ki = 514.0 nM 6.29
CHEMBL1369708 Ki = 523.0 nM 6.28
CHEMBL3785209 Ki = 549.0 nM 6.26
CHEMBL3787586 Ki = 547.0 nM 6.26
CHEMBL3633555 Ki = 565.0 nM 6.25
CHEMBL3785467 Ki = 618.0 nM 6.21
CHEMBL3786965 Ki = 652.0 nM 6.19
CHEMBL3787148 Ki = 683.0 nM 6.17
CHEMBL3785735 Ki = 711.0 nM 6.15
CHEMBL3785153 Ki = 728.0 nM 6.14