Assay Detail
Binding
CHEMBL3787808
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Inhibition of recombinant Candida glabrata beta carbonic anhydrase NCE103 expressed in Escherichia coli preincubated for 15 mins by stopped-flow CO2 hydration assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Nakaseomyces glabratus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Isatin analogs as novel inhibitors of Candida spp. β-carbonic anhydrase enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 7.40 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.96 |
| CHEMBL3785289 | — | — | 1 | 7.79 |
| CHEMBL3786724 | — | — | 1 | 7.67 |
| CHEMBL3765353 | — | — | 1 | 7.64 |
| CHEMBL3785846 | — | — | 1 | 7.64 |
| CHEMBL3787222 | — | — | 1 | 7.53 |
| CHEMBL3786969 | — | — | 1 | 7.49 |
| CHEMBL3785654 | — | — | 1 | 7.45 |
| CHEMBL3785827 | — | — | 1 | 7.44 |
| CHEMBL3786062 | — | — | 1 | 7.43 |
| CHEMBL3787472 | — | — | 1 | 7.42 |
| CHEMBL3785209 | — | — | 1 | 7.40 |
| CHEMBL3785591 | — | — | 1 | 7.35 |
| CHEMBL3787255 | — | — | 1 | 7.35 |
| CHEMBL3633555 | — | — | 1 | 7.34 |
| CHEMBL1369708 | — | — | 1 | 7.32 |
| CHEMBL3787586 | — | — | 1 | 7.30 |
| CHEMBL3786477 | — | — | 1 | 7.27 |
| CHEMBL3787489 | — | — | 1 | 7.26 |
| CHEMBL3786965 | — | — | 1 | 7.23 |
| CHEMBL3785735 | — | — | 1 | 7.21 |
| CHEMBL3785153 | — | — | 1 | 7.18 |
| CHEMBL3785467 | — | — | 1 | 7.07 |
| CHEMBL3787148 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL3785289 | — | Ki | = | 16.3 | nM | 7.79 |
| CHEMBL3786724 | — | Ki | = | 21.6 | nM | 7.67 |
| CHEMBL3765353 | — | Ki | = | 22.8 | nM | 7.64 |
| CHEMBL3785846 | — | Ki | = | 23.1 | nM | 7.64 |
| CHEMBL3787222 | — | Ki | = | 29.7 | nM | 7.53 |
| CHEMBL3786969 | — | Ki | = | 32.4 | nM | 7.49 |
| CHEMBL3785654 | — | Ki | = | 35.3 | nM | 7.45 |
| CHEMBL3785827 | — | Ki | = | 36.5 | nM | 7.44 |
| CHEMBL3786062 | — | Ki | = | 37.1 | nM | 7.43 |
| CHEMBL3787472 | — | Ki | = | 38.2 | nM | 7.42 |
| CHEMBL3785209 | — | Ki | = | 39.7 | nM | 7.40 |
| CHEMBL3785591 | — | Ki | = | 45.1 | nM | 7.35 |
| CHEMBL3787255 | — | Ki | = | 45.1 | nM | 7.35 |
| CHEMBL3633555 | — | Ki | = | 45.9 | nM | 7.34 |
| CHEMBL1369708 | — | Ki | = | 48.4 | nM | 7.32 |
| CHEMBL3787586 | — | Ki | = | 50.1 | nM | 7.30 |
| CHEMBL3786477 | — | Ki | = | 53.5 | nM | 7.27 |
| CHEMBL3787489 | — | Ki | = | 55.4 | nM | 7.26 |
| CHEMBL3786965 | — | Ki | = | 58.9 | nM | 7.23 |
| CHEMBL3785735 | — | Ki | = | 62.3 | nM | 7.21 |
| CHEMBL3785153 | — | Ki | = | 66.5 | nM | 7.18 |
| CHEMBL3785467 | — | Ki | = | 85.1 | nM | 7.07 |
| CHEMBL3787148 | — | Ki | = | 154.0 | nM | 6.81 |