Assay Detail
Functional
CHEMBL3787892
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by Hoechst 3342 staining analysis
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel optimization of valmerins (tetrahydropyrido[1,2-a]isoindolones) as potent dual CDK5/GSK3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.15 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3787480 | — | — | 1 | 7.40 |
| CHEMBL3786430 | — | — | 1 | 7.30 |
| CHEMBL3787135 | — | — | 1 | 7.22 |
| CHEMBL3785408 | — | — | 1 | 7.22 |
| CHEMBL3786276 | — | — | 1 | 7.16 |
| CHEMBL3785571 | — | — | 1 | 7.00 |
| CHEMBL3786536 | — | — | 1 | 6.82 |
| CHEMBL3785575 | — | — | 1 | 6.82 |
| CHEMBL3787557 | — | — | 1 | 6.82 |
| CHEMBL3787512 | — | — | 1 | 6.82 |
| CHEMBL3787081 | — | — | 1 | 6.75 |
| CHEMBL2180862 | — | — | 1 | 6.50 |
| CHEMBL3787033 | — | — | 1 | 6.30 |
| CHEMBL3787093 | — | — | 1 | 6.00 |
| CHEMBL3786624 | — | — | 1 | 5.82 |
| CHEMBL3785771 | — | — | 1 | 5.82 |
| CHEMBL2180863 | — | — | 1 | 5.82 |
| CHEMBL3785795 | — | — | 1 | 5.70 |
| CHEMBL3786332 | — | — | 1 | 5.70 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 5.52 |
| CHEMBL3785804 | — | — | 1 | 5.30 |
| CHEMBL3787292 | — | — | 1 | 5.05 |
| CHEMBL3786745 | — | — | 1 | 4.82 |
| CHEMBL3785596 | — | — | 1 | 4.82 |
| CHEMBL3787061 | — | — | 1 | 4.70 |
| CHEMBL3785573 | — | — | 1 | 4.70 |
| CHEMBL3787584 | — | — | 1 | - |
| CHEMBL3786657 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3787480 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3786430 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3787135 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3785408 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3786276 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3785571 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3786536 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3785575 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3787557 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3787512 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3787081 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2180862 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3787033 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3787093 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3786624 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3785771 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2180863 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3785795 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3786332 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3785804 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3787292 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3786745 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3785596 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3787061 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3785573 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3787584 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL3786657 | — | IC50 | > | 25000.0 | nM | - |