Assay Detail
Binding
CHEMBL3787907
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Inhibition of human recombinant MAO-A using kynuramine as substrate after 30 mins by fluorescence spectrophotometry
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.67 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 8.57 |
| CHEMBL3786785 | — | — | 1 | 7.55 |
| CHEMBL3786747 | — | — | 1 | 6.94 |
| CHEMBL2288402 | — | — | 1 | 6.63 |
| CHEMBL3263556 | — | — | 1 | 6.57 |
| CHEMBL3786282 | — | — | 1 | 6.34 |
| CHEMBL1814450 | — | — | 1 | 5.97 |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 5.85 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3786785 | — | IC50 | = | 27.9 | nM | 7.55 |
| CHEMBL3786747 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL2288402 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL3263556 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL3786282 | — | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL1814450 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL887 | RASAGILINE | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 2560.0 | nM | 5.59 |