Assay Detail
Binding
CHEMBL3787909
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Inhibition of human recombinant MAO-B using kynuramine as substrate after 30 mins by fluorescence spectrophotometry
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.07 | 7.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | 4.0 | 1 | 7.08 |
| CHEMBL3786378 | — | — | 1 | 6.65 |
| CHEMBL3786747 | — | — | 1 | 6.48 |
| CHEMBL1814450 | — | — | 1 | 6.47 |
| CHEMBL3786282 | — | — | 1 | 6.41 |
| CHEMBL3263556 | — | — | 1 | 6.41 |
| CHEMBL3785406 | — | — | 1 | 6.15 |
| CHEMBL3786785 | — | — | 1 | 6.09 |
| CHEMBL3786723 | — | — | 1 | 5.82 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.71 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 5.38 |
| CHEMBL2288402 | — | — | 1 | 5.23 |
| CHEMBL3787128 | — | — | 1 | 4.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL887 | RASAGILINE | IC50 | = | 82.5 | nM | 7.08 |
| CHEMBL3786378 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL3786747 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL1814450 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3786282 | — | IC50 | = | 391.0 | nM | 6.41 |
| CHEMBL3263556 | — | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL3785406 | — | IC50 | = | 703.0 | nM | 6.15 |
| CHEMBL3786785 | — | IC50 | = | 808.0 | nM | 6.09 |
| CHEMBL3786723 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL8706 | CLORGILINE | IC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL2288402 | — | IC50 | = | 5940.0 | nM | 5.23 |
| CHEMBL3787128 | — | IC50 | = | 10800.0 | nM | 4.97 |