Assay Detail
Functional
CHEMBL3787925
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human delta opioid receptor expressed in CHO cell membranes by [35S]GTPgammaS binding assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of novel opioid ligands with a C-homomorphinan skeleton.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.60 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3787263 | — | — | 1 | 9.09 |
| CHEMBL3787016 | — | — | 1 | 8.97 |
| CHEMBL3785854 | — | — | 1 | 8.85 |
| CHEMBL3786083 | — | — | 1 | 8.74 |
| CHEMBL3785265 | — | — | 1 | 8.50 |
| CHEMBL3787663 | — | — | 1 | 8.13 |
| CHEMBL3786970 | — | — | 1 | 7.90 |
| CHEMBL3786218 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3787263 | — | EC50 | = | 0.813 | nM | 9.09 |
| CHEMBL3787016 | — | EC50 | = | 1.06 | nM | 8.97 |
| CHEMBL3785854 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3786083 | — | EC50 | = | 1.83 | nM | 8.74 |
| CHEMBL3785265 | — | EC50 | = | 3.17 | nM | 8.50 |
| CHEMBL3787663 | — | EC50 | = | 7.32 | nM | 8.13 |
| CHEMBL3786970 | — | EC50 | = | 12.5 | nM | 7.90 |
| CHEMBL3786218 | — | EC50 | > | 10000.0 | nM | - |