Assay Detail
Binding
CHEMBL3788090
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type HIV1 Reverse transcriptase assessed as reduction of biotin deoxyuridine triphosphate incorporation into the wild type HIV1 reverse transcriptase after 1 hr by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, synthesis and evaluation of novel HIV-1 NNRTIs with dual structural conformations targeting the entrance channel of the NNRTI binding pocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.90 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3786091 | — | — | 1 | 7.14 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 5.51 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3786091 | — | IC50 | = | 72.7 | nM | 7.14 |
| CHEMBL308954 | ETRAVIRINE | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 8800.0 | nM | 5.06 |