Assay Detail
Binding
CHEMBL3788095
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Inhibition of rat liver thioredoxin reductase after 60 mins by DTNB reduction assay in presence of NADPH
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Applying the designed multiple ligands approach to inhibit dihydrofolate reductase and thioredoxin reductase for anti-proliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.10 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3787235 | — | — | 1 | 5.58 |
| CHEMBL3787681 | — | — | 1 | 5.38 |
| CHEMBL3785320 | — | — | 1 | 5.27 |
| CHEMBL3787397 | — | — | 1 | 5.00 |
| CHEMBL7976 | CHALCONE | — | 1 | 4.97 |
| CHEMBL3785981 | — | — | 1 | 4.90 |
| CHEMBL104732 | — | — | 1 | 4.61 |
| CHEMBL532909 | — | — | 1 | - |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3787235 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL3787681 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3785320 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3787397 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL7976 | CHALCONE | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL3785981 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL104732 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL532909 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL34259 | METHOTREXATE | IC50 | > | 100000.0 | nM | - |