Assay Detail
Binding
CHEMBL3788097
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human alpha7 nAChR expressed in xenopus oocytes preincubated for 10 mins followed by acetylcholine addition by patch clamp electrophysiological assay
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 48 | 5.38 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2151572 | ENCENICLINE | 3.0 | 1 | 6.47 |
| CHEMBL3786240 | — | — | 1 | 5.75 |
| CHEMBL3785589 | — | — | 1 | 5.67 |
| CHEMBL3786561 | — | — | 1 | 5.60 |
| CHEMBL3787650 | — | — | 1 | 5.55 |
| CHEMBL3787063 | — | — | 1 | 5.45 |
| CHEMBL3786124 | — | — | 1 | 5.40 |
| CHEMBL3787561 | — | — | 1 | 5.40 |
| CHEMBL3787485 | — | — | 1 | 5.33 |
| CHEMBL3786427 | — | — | 1 | 5.32 |
| CHEMBL3786711 | — | — | 1 | 5.16 |
| CHEMBL3786820 | — | — | 1 | 5.08 |
| CHEMBL3786022 | — | — | 1 | 5.07 |
| CHEMBL3785274 | — | — | 1 | 5.02 |
| CHEMBL3786847 | — | — | 1 | 4.98 |
| CHEMBL3787101 | — | — | 1 | 4.85 |
| CHEMBL3786196 | — | — | 1 | - |
| CHEMBL3786664 | — | — | 1 | - |
| CHEMBL3787649 | — | — | 1 | - |
| CHEMBL3785578 | — | — | 1 | - |
| CHEMBL3786458 | — | — | 1 | - |
| CHEMBL3785483 | — | — | 1 | - |
| CHEMBL3786757 | — | — | 1 | - |
| CHEMBL3787659 | — | — | 1 | - |
| CHEMBL3787203 | — | — | 1 | - |
| CHEMBL3786064 | — | — | 1 | - |
| CHEMBL3786302 | — | — | 1 | - |
| CHEMBL3786349 | — | — | 1 | - |
| CHEMBL3786288 | — | — | 1 | - |
| CHEMBL3786509 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2151572 | ENCENICLINE | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL3786240 | — | EC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL3785589 | — | EC50 | = | 2140.0 | nM | 5.67 |
| CHEMBL3786561 | — | EC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL3787650 | — | EC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL3787063 | — | EC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL3786124 | — | EC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL3787561 | — | EC50 | = | 3990.0 | nM | 5.40 |
| CHEMBL3787485 | — | EC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL3786427 | — | EC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL3786711 | — | EC50 | = | 6920.0 | nM | 5.16 |
| CHEMBL3786820 | — | EC50 | = | 8380.0 | nM | 5.08 |
| CHEMBL3786022 | — | EC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL3785274 | — | EC50 | = | 9630.0 | nM | 5.02 |
| CHEMBL3786847 | — | EC50 | = | 10480.0 | nM | 4.98 |
| CHEMBL3787101 | — | EC50 | = | 14130.0 | nM | 4.85 |
| CHEMBL3785383 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3786875 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3786604 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3786699 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3786717 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3787259 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3785700 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3785845 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3785097 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3787199 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3787676 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3786366 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3787675 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3787416 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3787585 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3785410 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3786253 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3786273 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3786509 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3786288 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3786349 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3786302 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3786064 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3787203 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3787659 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3786757 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3785483 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3786458 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3785578 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3787649 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3786664 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3786196 | — | EC50 | > | 20000.0 | nM | - |