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Assay Detail

CHEMBL3788335

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-MLA from human alpha7 nAChR expressed in xenopus oocytes
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists.
Xue Y, Tang J, Ma X, Li Q, Xie B, Hao Y, Jin H, Wang K, Zhang G, Zhang L, Zhang L.
Eur J Med Chem (2016) 115 : 94 -108
PubMed 26994846 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 7.83 7.83

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3786240 1 7.83

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3786240 Ki = 14.9 nM 7.83