Assay Detail
Functional
CHEMBL3788417
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Anticoagulant activity in rat citrated plasma assessed as thrombin clotting time after 1 min by coagulometry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of AZD8165 a clinical candidate from a novel series of neutral thrombin inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.67 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3787587 | — | — | 1 | 7.89 |
| CHEMBL3787458 | — | — | 1 | 7.75 |
| CHEMBL3785476 | — | — | 1 | 7.70 |
| CHEMBL3786799 | — | — | 1 | 7.70 |
| CHEMBL3785556 | — | — | 1 | 7.64 |
| CHEMBL3785177 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3787587 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3787458 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3785476 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3786799 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3785556 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3785177 | — | IC50 | = | 45.0 | nM | 7.35 |