Assay Detail
Functional
CHEMBL3788461
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at mouse TAAR5 expressed in HEK293 cells assessed as inhibition of agonist induced cAMP release preincubated for 5 mins followed by addition of agonist by BRET assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Trace amine-associated receptor 5 (CHEMBL3784908) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.93 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1962870 | — | — | 1 | 5.32 |
| CHEMBL1962769 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1962870 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1962769 | — | IC50 | = | 29000.0 | nM | 4.54 |