Assay Detail
Functional
CHEMBL3788796
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Antiviral activity against HCV genotype 1b harboring NS3/4A protease R155K mutant infected in human HuH7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR method in presence of 10% fetal bovine serum
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 8.73 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3787685 | — | — | 1 | 9.22 |
| CHEMBL3786672 | — | — | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3787685 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL3786672 | — | EC50 | = | 5.7 | nM | 8.24 |