Assay Detail
Binding
CHEMBL3788932
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human C-terminal FLAG-tagged KDM5A (1 to 1090 residues) expressed in baculovirus infected sf9 cells using biotin-H3K4me3 substrate incubated for 30 mins by TR-FRET assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Progress in Histone Demethylase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.83 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3786803 | — | — | 1 | 7.00 |
| CHEMBL3786225 | — | — | 1 | 7.00 |
| CHEMBL3786596 | — | — | 1 | 7.00 |
| CHEMBL3787548 | — | — | 1 | 7.00 |
| CHEMBL3785421 | — | — | 1 | 7.00 |
| CHEMBL3786108 | — | — | 1 | 6.00 |
| CHEMBL3787133 | — | — | 1 | - |
| CHEMBL3787664 | — | — | 1 | - |
| CHEMBL3785832 | — | — | 1 | - |
| CHEMBL3786952 | — | — | 1 | - |
| CHEMBL3786579 | — | — | 1 | - |
| CHEMBL3785470 | — | — | 1 | - |
| CHEMBL3786617 | — | — | 1 | - |
| CHEMBL3787438 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3786803 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3786225 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3786596 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3787548 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3785421 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3786108 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3787133 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL3787664 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL3785832 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL3786952 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL3786579 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL3785470 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL3786617 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL3787438 | — | IC50 | < | 100.0 | nM | - |