Assay Detail
Binding
CHEMBL3788937
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Inhibition of KDM5A in human ZR-75-1 cells assessed as reduction in H3K4me3 demethylation incubated for 72 hrs by fluorometric immunoassay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | ZR-75-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Progress in Histone Demethylase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.67 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3785832 | — | — | 1 | 7.00 |
| CHEMBL3786987 | — | — | 1 | 7.00 |
| CHEMBL3785470 | — | — | 1 | 7.00 |
| CHEMBL3786617 | — | — | 1 | 7.00 |
| CHEMBL3786803 | — | — | 1 | 6.00 |
| CHEMBL3787664 | — | — | 1 | 6.00 |
| CHEMBL3787133 | — | — | 1 | - |
| CHEMBL3786225 | — | — | 1 | - |
| CHEMBL3786952 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3785832 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3786987 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3785470 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3786617 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3786803 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3787664 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3787133 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3786225 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3786952 | — | IC50 | < | 100.0 | nM | - |