Assay Detail
Functional
CHEMBL3788955
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Cytotoxicity against human Bcap37 cells after 48 hrs by MTT assay
79
Total Activities
79
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Bcap37 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dihydropyrazole derivatives as telomerase inhibitors: Structure-based design, synthesis, SAR and anticancer evaluation in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 79 | 4.76 | 5.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.95 |
| CHEMBL3786636 | — | — | 1 | 5.66 |
| CHEMBL3786231 | — | — | 1 | 5.47 |
| CHEMBL3785907 | — | — | 1 | 5.46 |
| CHEMBL3787509 | — | — | 1 | 5.38 |
| CHEMBL3787504 | — | — | 1 | 5.30 |
| CHEMBL3785132 | — | — | 1 | 5.30 |
| CHEMBL3785712 | — | — | 1 | 5.29 |
| CHEMBL3786451 | — | — | 1 | 5.28 |
| CHEMBL3785170 | — | — | 1 | 5.27 |
| CHEMBL3785281 | — | — | 1 | 5.21 |
| CHEMBL3787157 | — | — | 1 | 5.20 |
| CHEMBL3786821 | — | — | 1 | 5.19 |
| CHEMBL3785664 | — | — | 1 | 5.17 |
| CHEMBL3786261 | — | — | 1 | 5.17 |
| CHEMBL3785699 | — | — | 1 | 5.09 |
| CHEMBL3786130 | — | — | 1 | 5.03 |
| CHEMBL3785833 | — | — | 1 | 5.01 |
| CHEMBL3787256 | — | — | 1 | 5.00 |
| CHEMBL1770487 | — | — | 1 | 5.00 |
| CHEMBL3785474 | — | — | 1 | 4.91 |
| CHEMBL3787380 | — | — | 1 | 4.89 |
| CHEMBL3786296 | — | — | 1 | 4.85 |
| CHEMBL3787163 | — | — | 1 | 4.82 |
| CHEMBL3785595 | — | — | 1 | 4.81 |
| CHEMBL3785339 | — | — | 1 | 4.77 |
| CHEMBL3785758 | — | — | 1 | 4.75 |
| CHEMBL3787196 | — | — | 1 | 4.73 |
| CHEMBL3785794 | — | — | 1 | 4.73 |
| CHEMBL3786766 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL3786636 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL3786231 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL3785907 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3787509 | — | IC50 | = | 4220.0 | nM | 5.38 |
| CHEMBL3787504 | — | IC50 | = | 4960.0 | nM | 5.30 |
| CHEMBL3785132 | — | IC50 | = | 4950.0 | nM | 5.30 |
| CHEMBL3785712 | — | IC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL3786451 | — | IC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL3785170 | — | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL3785281 | — | IC50 | = | 6210.0 | nM | 5.21 |
| CHEMBL3787157 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3786821 | — | IC50 | = | 6490.0 | nM | 5.19 |
| CHEMBL3786261 | — | IC50 | = | 6810.0 | nM | 5.17 |
| CHEMBL3785664 | — | IC50 | = | 6740.0 | nM | 5.17 |
| CHEMBL3785699 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL3786130 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL3785833 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL3787256 | — | IC50 | = | 9980.0 | nM | 5.00 |
| CHEMBL1770487 | — | IC50 | = | 9970.0 | nM | 5.00 |
| CHEMBL3785474 | — | IC50 | = | 12190.0 | nM | 4.91 |
| CHEMBL3787380 | — | IC50 | = | 12780.0 | nM | 4.89 |
| CHEMBL3786296 | — | IC50 | = | 14220.0 | nM | 4.85 |
| CHEMBL3787163 | — | IC50 | = | 15280.0 | nM | 4.82 |
| CHEMBL3785595 | — | IC50 | = | 15470.0 | nM | 4.81 |
| CHEMBL3785339 | — | IC50 | = | 16920.0 | nM | 4.77 |
| CHEMBL3785758 | — | IC50 | = | 17890.0 | nM | 4.75 |
| CHEMBL3787196 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL3785794 | — | IC50 | = | 18750.0 | nM | 4.73 |
| CHEMBL3786766 | — | IC50 | = | 19420.0 | nM | 4.71 |
| CHEMBL3787476 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL3785565 | — | IC50 | = | 20570.0 | nM | 4.69 |
| CHEMBL3786308 | — | IC50 | = | 20890.0 | nM | 4.68 |
| CHEMBL3785506 | — | IC50 | = | 20840.0 | nM | 4.68 |
| CHEMBL3786111 | — | IC50 | = | 24210.0 | nM | 4.62 |
| CHEMBL3786236 | — | IC50 | = | 25220.0 | nM | 4.60 |
| CHEMBL3785883 | — | IC50 | = | 25660.0 | nM | 4.59 |
| CHEMBL3785244 | — | IC50 | = | 26070.0 | nM | 4.58 |
| CHEMBL3786210 | — | IC50 | = | 27210.0 | nM | 4.57 |
| CHEMBL3786734 | — | IC50 | = | 26690.0 | nM | 4.57 |
| CHEMBL3785738 | — | IC50 | = | 28570.0 | nM | 4.54 |
| CHEMBL3786826 | — | IC50 | = | 29670.0 | nM | 4.53 |
| CHEMBL3787298 | — | IC50 | = | 30300.0 | nM | 4.52 |
| CHEMBL1770491 | — | IC50 | = | 30170.0 | nM | 4.52 |
| CHEMBL3786422 | — | IC50 | = | 32580.0 | nM | 4.49 |
| CHEMBL3785970 | — | IC50 | = | 32170.0 | nM | 4.49 |
| CHEMBL3781973 | — | IC50 | = | 32320.0 | nM | 4.49 |
| CHEMBL3787002 | — | IC50 | = | 33140.0 | nM | 4.48 |
| CHEMBL3786268 | — | IC50 | = | 33710.0 | nM | 4.47 |
| CHEMBL3786450 | — | IC50 | = | 34210.0 | nM | 4.47 |