Assay Detail
Functional
CHEMBL3789065
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at NTSR1 in human HT-29 cells assessed as induction of intracellular Ca2+ mobilization by fura-2 dye-based spectrofluorimetric analysis
12
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mimicking of Arginine by Functionalized N(ω)-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.79 | 8.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415788 | — | — | 2 | 8.88 |
| CHEMBL3786852 | — | — | 2 | 8.81 |
| CHEMBL3786291 | — | — | 2 | 8.70 |
| CHEMBL3786779 | — | — | 1 | - |
| CHEMBL3787200 | — | — | 1 | - |
| CHEMBL3787095 | — | — | 1 | - |
| CHEMBL4299304 | — | — | 1 | - |
| CHEMBL3785233 | — | — | 1 | - |
| CHEMBL3786771 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415788 | — | EC50 | = | 1.318 | nM | 8.88 |
| CHEMBL415788 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3786852 | — | EC50 | = | 1.549 | nM | 8.81 |
| CHEMBL3786852 | — | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3786291 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3786291 | — | EC50 | = | 1.995 | nM | 8.70 |
| CHEMBL3786779 | — | EC50 | - | — | - | |
| CHEMBL3787200 | — | EC50 | - | — | - | |
| CHEMBL3787095 | — | EC50 | - | — | - | |
| CHEMBL4299304 | — | EC50 | - | — | - | |
| CHEMBL3785233 | — | EC50 | - | — | - | |
| CHEMBL3786771 | — | EC50 | - | — | - |