Assay Detail
Binding
CHEMBL3789067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-{Nomega-[N-(4-propanoylaminobutyl)aminocarbonyl]}Arg-Arg-ProTyr-Ile-Leu-OH Tris(hydrotrifluoroacetate) from NTSR1 in human HT-29 cells after 2 hrs by liquid scintillation counting
16
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mimicking of Arginine by Functionalized N(ω)-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 9.23 | 9.85 |
| IC50 | 6 | 8.78 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415788 | — | — | 2 | 9.85 |
| CHEMBL3786779 | — | — | 1 | 9.59 |
| CHEMBL3785233 | — | — | 1 | 9.44 |
| CHEMBL3787200 | — | — | 1 | 9.39 |
| CHEMBL3786852 | — | — | 2 | 9.33 |
| CHEMBL3786291 | — | — | 2 | 9.33 |
| CHEMBL3786771 | — | — | 2 | 9.23 |
| CHEMBL3040381 | — | — | 2 | 8.96 |
| CHEMBL3787095 | — | — | 2 | 8.77 |
| CHEMBL4299304 | — | — | 1 | 8.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415788 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL3786779 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL3785233 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL3787200 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL415788 | — | IC50 | = | 0.4074 | nM | 9.39 |
| CHEMBL3786852 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL3786291 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL3786771 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL3040381 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL3786291 | — | IC50 | = | 1.349 | nM | 8.87 |
| CHEMBL3786852 | — | IC50 | = | 1.349 | nM | 8.87 |
| CHEMBL3787095 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL3786771 | — | IC50 | = | 1.738 | nM | 8.76 |
| CHEMBL3040381 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL4299304 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL3787095 | — | IC50 | = | 5.012 | nM | 8.30 |