Assay Detail
Binding
CHEMBL3789104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human RIP1 (1 to 375 residues) preincubated for 10 mins measured after 20 mins by fluorescence polarization assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 1 (CHEMBL5464) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.20 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3785703 | — | — | 1 | 8.00 |
| CHEMBL3109202 | — | — | 1 | 7.60 |
| CHEMBL3786293 | — | — | 1 | 7.50 |
| CHEMBL3786162 | — | — | 1 | 7.40 |
| CHEMBL3786778 | — | — | 1 | 6.50 |
| CHEMBL370438 | — | — | 1 | 6.20 |
| CHEMBL3787216 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3785703 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3109202 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3786293 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3786162 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3786778 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL370438 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL3787216 | — | IC50 | > | 10000.0 | nM | - |