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Assay Detail

CHEMBL3789169

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of KDM4E (unknown origin) preincubated for 15 mins followed by histone substrate addition measured after 1 hr by alphascreen assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Lysine-specific demethylase 4E (CHEMBL1293226)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Recent Progress in Histone Demethylase Inhibitors.
McAllister TE, England KS, Hopkinson RJ, Brennan PE, Kawamura A, Schofield CJ.
J Med Chem (2016) 59 : 1308 -1329
PubMed 26710088 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.30 5.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3785164 1 5.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3785164 IC50 = 5000.0 nM 5.30