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Assay Detail

CHEMBL3789227

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Functional
Antileishmanial activity against amastigote stage of Leishmania infantum infected in mouse primary peritoneal macrophages assessed as parasite growth inhibition incubated for 5 days by Giemsa staining-based microscopic analysis
ChEMBL ↗
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania infantum
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania infantum (CHEMBL612848) ↗
Type ORGANISM
Organism Leishmania infantum

Publication

Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis.
Thompson AM, O'Connor PD, Blaser A, Yardley V, Maes L, Gupta S, Launay D, Martin D, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA.
J Med Chem (2016) 59 : 2530 -2550
PubMed 26901446 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 67 5.89 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3787272 — — 1 7.52
CHEMBL3786164 — — 1 7.52
CHEMBL3785739 — — 1 7.22
CHEMBL3785196 — — 1 6.96
CHEMBL3785138 — — 1 6.89
CHEMBL3785985 — — 1 6.85
CHEMBL3785856 — — 1 6.82
CHEMBL3787572 — — 1 6.77
CHEMBL218974 — — 1 6.77
CHEMBL3787314 — — 1 6.70
CHEMBL3786828 — — 1 6.70
CHEMBL3786301 — — 1 6.64
CHEMBL3786648 — — 1 6.62
CHEMBL3787306 — — 1 6.55
CHEMBL219919 — — 1 6.52
CHEMBL3786795 — — 1 6.51
CHEMBL3786138 — — 1 6.50
CHEMBL3786030 — — 1 6.48
CHEMBL3786077 — — 1 6.48
CHEMBL3787583 — — 1 6.39
CHEMBL3785572 — — 1 6.37
CHEMBL3786151 — — 1 6.30
CHEMBL3785182 — — 1 6.30
CHEMBL3787513 — — 1 6.30
CHEMBL3786902 — — 1 6.26
CHEMBL3787439 — — 1 6.24
CHEMBL3785579 — — 1 6.12
CHEMBL3786215 — — 1 6.11
CHEMBL3786471 — — 1 6.08
CHEMBL3786741 — — 1 5.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3787272 — IC50 = 30.0 nM 7.52
CHEMBL3786164 — IC50 = 30.0 nM 7.52
CHEMBL3785739 — IC50 = 60.0 nM 7.22
CHEMBL3785196 — IC50 = 110.0 nM 6.96
CHEMBL3785138 — IC50 = 130.0 nM 6.89
CHEMBL3785985 — IC50 = 140.0 nM 6.85
CHEMBL3785856 — IC50 = 150.0 nM 6.82
CHEMBL3787572 — IC50 = 170.0 nM 6.77
CHEMBL218974 — IC50 = 170.0 nM 6.77
CHEMBL3787314 — IC50 = 200.0 nM 6.70
CHEMBL3786828 — IC50 = 200.0 nM 6.70
CHEMBL3786301 — IC50 = 230.0 nM 6.64
CHEMBL3786648 — IC50 = 240.0 nM 6.62
CHEMBL3787306 — IC50 = 280.0 nM 6.55
CHEMBL219919 — IC50 = 300.0 nM 6.52
CHEMBL3786795 — IC50 = 310.0 nM 6.51
CHEMBL3786138 — IC50 = 320.0 nM 6.50
CHEMBL3786030 — IC50 = 330.0 nM 6.48
CHEMBL3786077 — IC50 = 330.0 nM 6.48
CHEMBL3787583 — IC50 = 410.0 nM 6.39
CHEMBL3785572 — IC50 = 430.0 nM 6.37
CHEMBL3786151 — IC50 = 500.0 nM 6.30
CHEMBL3785182 — IC50 = 500.0 nM 6.30
CHEMBL3787513 — IC50 = 500.0 nM 6.30
CHEMBL3786902 — IC50 = 550.0 nM 6.26
CHEMBL3787439 — IC50 = 570.0 nM 6.24
CHEMBL3785579 — IC50 = 760.0 nM 6.12
CHEMBL3786215 — IC50 = 770.0 nM 6.11
CHEMBL3786471 — IC50 = 830.0 nM 6.08
CHEMBL3786741 — IC50 = 1400.0 nM 5.85
CHEMBL3785276 — IC50 = 1500.0 nM 5.82
CHEMBL3787018 — IC50 = 1700.0 nM 5.77
CHEMBL3787358 — IC50 = 1800.0 nM 5.75
CHEMBL3785677 — IC50 = 2200.0 nM 5.66
CHEMBL3785566 — IC50 = 2300.0 nM 5.64
CHEMBL3785829 — IC50 = 2400.0 nM 5.62
CHEMBL3785539 — IC50 = 2900.0 nM 5.54
CHEMBL3787057 — IC50 = 3300.0 nM 5.48
CHEMBL3786175 — IC50 = 3600.0 nM 5.44
CHEMBL3787645 — IC50 = 3800.0 nM 5.42
CHEMBL3786438 — IC50 = 4200.0 nM 5.38
CHEMBL3787143 — IC50 = 5000.0 nM 5.30
CHEMBL3787138 — IC50 = 5300.0 nM 5.28
CHEMBL3787545 — IC50 = 5200.0 nM 5.28
CHEMBL218650 DELAMANID IC50 = 7100.0 nM 5.15
CHEMBL3787357 — IC50 = 11000.0 nM 4.96
CHEMBL3785128 — IC50 = 11000.0 nM 4.96
CHEMBL3188499 — IC50 = 13000.0 nM 4.89
CHEMBL3785116 — IC50 = 18000.0 nM 4.75
CHEMBL3787070 — IC50 = 26000.0 nM 4.58