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Assay Detail

CHEMBL3789230

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human MRC5 cells assessed as cell viability incubated for 72 hrs by fluorimetric assay
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type MRC5
Confidence 1 — Organism
Curated By Autocuration

Target

MRC5 (CHEMBL614181)
Type CELL-LINE
Organism Homo sapiens

Publication

Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis.
Thompson AM, O'Connor PD, Blaser A, Yardley V, Maes L, Gupta S, Launay D, Martin D, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA.
J Med Chem (2016) 59 : 2530 -2550
PubMed 26901446 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 67 4.40 4.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3786506 1 4.60
CHEMBL3785246 1 4.58
CHEMBL3787290 1 4.51
CHEMBL3785867 1 4.47
CHEMBL3787258 1 4.42
CHEMBL3785947 1 4.37
CHEMBL3785829 1 4.35
CHEMBL3787143 1 4.33
CHEMBL3786481 1 4.27
CHEMBL3785669 1 4.26
CHEMBL3787306 1 4.22
CHEMBL218650 DELAMANID 4.0 1 -
CHEMBL3188499 1 -
CHEMBL3787018 1 -
CHEMBL3786301 1 -
CHEMBL3786828 1 -
CHEMBL3787439 1 -
CHEMBL3786795 1 -
CHEMBL3785985 1 -
CHEMBL3787622 1 -
CHEMBL3786438 1 -
CHEMBL3785128 1 -
CHEMBL3787138 1 -
CHEMBL3785539 1 -
CHEMBL3786175 1 -
CHEMBL3787070 1 -
CHEMBL3785138 1 -
CHEMBL3787545 1 -
CHEMBL3785566 1 -
CHEMBL3787357 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3786506 IC50 = 25000.0 nM 4.60
CHEMBL3785246 IC50 = 26000.0 nM 4.58
CHEMBL3787290 IC50 = 31000.0 nM 4.51
CHEMBL3785867 IC50 = 34000.0 nM 4.47
CHEMBL3787258 IC50 = 38000.0 nM 4.42
CHEMBL3785947 IC50 = 43000.0 nM 4.37
CHEMBL3785829 IC50 = 45000.0 nM 4.35
CHEMBL3787143 IC50 = 47000.0 nM 4.33
CHEMBL3786481 IC50 = 54000.0 nM 4.27
CHEMBL3785669 IC50 = 55000.0 nM 4.26
CHEMBL3787306 IC50 = 60000.0 nM 4.22
CHEMBL3786335 IC50 > 64000.0 nM -
CHEMBL3787583 IC50 > 64000.0 nM -
CHEMBL3787466 IC50 > 64000.0 nM -
CHEMBL3786950 IC50 > 64000.0 nM -
CHEMBL3785978 IC50 > 64000.0 nM -
CHEMBL3787410 IC50 > 64000.0 nM -
CHEMBL3785196 IC50 > 64000.0 nM -
CHEMBL3786151 IC50 > 64000.0 nM -
CHEMBL3785856 IC50 > 64000.0 nM -
CHEMBL3786077 IC50 > 64000.0 nM -
CHEMBL3787513 IC50 > 64000.0 nM -
CHEMBL3786387 IC50 > 64000.0 nM -
CHEMBL3786769 IC50 > 64000.0 nM -
CHEMBL3786030 IC50 > 64000.0 nM -
CHEMBL218974 IC50 > 64000.0 nM -
CHEMBL3786215 IC50 > 64000.0 nM -
CHEMBL219919 IC50 > 64000.0 nM -
CHEMBL3787572 IC50 > 64000.0 nM -
CHEMBL3787314 IC50 > 64000.0 nM -
CHEMBL3786438 IC50 > 64000.0 nM -
CHEMBL3787357 IC50 > 64000.0 nM -
CHEMBL3785566 IC50 > 64000.0 nM -
CHEMBL3787545 IC50 > 64000.0 nM -
CHEMBL3785138 IC50 > 64000.0 nM -
CHEMBL3787070 IC50 > 64000.0 nM -
CHEMBL3786175 IC50 > 64000.0 nM -
CHEMBL3785539 IC50 > 64000.0 nM -
CHEMBL3787138 IC50 > 64000.0 nM -
CHEMBL3785128 IC50 > 64000.0 nM -
CHEMBL3787254 IC50 > 64000.0 nM -
CHEMBL3787622 IC50 > 64000.0 nM -
CHEMBL3785985 IC50 > 64000.0 nM -
CHEMBL3786795 IC50 > 64000.0 nM -
CHEMBL3787439 IC50 > 64000.0 nM -
CHEMBL3786828 IC50 > 64000.0 nM -
CHEMBL3786301 IC50 > 64000.0 nM -
CHEMBL3787018 IC50 > 64000.0 nM -
CHEMBL3188499 IC50 > 64000.0 nM -
CHEMBL218650 DELAMANID IC50 > 64000.0 nM -