Assay Detail
Binding
CHEMBL3789356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse RIP1 15 point mutant transfected in HEK293T cells assessed as reduction in S166 phosphorylation by ELISA
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK-293T |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.75 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3785703 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3785703 | — | IC50 | = | 18.0 | nM | 7.75 |