Assay Detail
Binding
CHEMBL3789357
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse RIP1 V159L/T164M/Q176L/S180D/S181G mutant transfected in HEK293T cells assessed as reduction in S166 phosphorylation by ELISA
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK-293T |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.92 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3785703 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3785703 | — | IC50 | = | 12.0 | nM | 7.92 |