Assay Detail
Binding
CHEMBL3789404
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Inhibition of Jak1 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.58 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3787112 | — | — | 1 | 6.58 |
| CHEMBL1614712 | — | — | 1 | - |
| CHEMBL3787614 | — | — | 1 | - |
| CHEMBL3786567 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3787112 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1614712 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3787614 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3786567 | — | IC50 | > | 10000.0 | nM | - |