Assay Detail
Binding
CHEMBL3789405
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDR (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.56 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3787112 | — | — | 1 | 6.36 |
| CHEMBL3787614 | — | — | 1 | 5.18 |
| CHEMBL1614712 | — | — | 1 | 5.15 |
| CHEMBL3786567 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3787112 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL3787614 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL1614712 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL3786567 | — | IC50 | > | 10000.0 | nM | - |