Assay Detail
Binding
CHEMBL3789428
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged recombinant human full length PI4K3beta expressed in insect cells preincubated for 15 mins followed by addition of cold ATP/gamma32P-ATP measured after 30 mins in presence of MgCl2
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.05 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3786230 | — | — | 1 | 8.44 |
| CHEMBL3787013 | — | — | 1 | 8.38 |
| CHEMBL3786633 | — | — | 1 | 8.36 |
| CHEMBL3787634 | — | — | 1 | 8.28 |
| CHEMBL3785630 | — | — | 1 | 8.26 |
| CHEMBL3785311 | — | — | 1 | 8.15 |
| CHEMBL3786159 | — | — | 1 | 7.80 |
| CHEMBL1229535 | — | — | 1 | 7.77 |
| CHEMBL3787054 | — | — | 1 | 7.64 |
| CHEMBL3785694 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3786230 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL3787013 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL3786633 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3787634 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL3785630 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL3785311 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3786159 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1229535 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3787054 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3785694 | — | IC50 | = | 36.0 | nM | 7.44 |