Assay Detail
Binding
CHEMBL3789429
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of histidine-tagged recombinant human full length PI3Kgamma expressed in insect cells preincubated for 15 mins followed by addition of cold ATP/gamma32P-ATP measured after 15 mins in presence of MgCl2
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.66 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3787013 | — | — | 1 | 8.30 |
| CHEMBL1229535 | — | — | 1 | 7.77 |
| CHEMBL3787634 | — | — | 1 | 7.68 |
| CHEMBL3787054 | — | — | 1 | 7.51 |
| CHEMBL3786633 | — | — | 1 | 6.74 |
| CHEMBL3785311 | — | — | 1 | 5.98 |
| CHEMBL3786159 | — | — | 1 | 5.82 |
| CHEMBL3785630 | — | — | 1 | 5.43 |
| CHEMBL3786230 | — | — | 1 | 4.70 |
| CHEMBL3785694 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3787013 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1229535 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3787634 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3787054 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3786633 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL3785311 | — | IC50 | = | 1046.0 | nM | 5.98 |
| CHEMBL3786159 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3785630 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3786230 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3785694 | — | IC50 | > | 50000.0 | nM | - |