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Assay Detail

CHEMBL3789657

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HeLa cells after 24 hrs by [3H]-thymidine incorporation assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Derivatization of agelastatin A leading to bioactive analogs and a trifunctional probe.
Jouanneau M, McClary B, Reyes JC, Chen R, Chen Y, Plunkett W, Cheng X, Milinichik AZ, Albone EF, Liu JO, Romo D.
Bioorg Med Chem Lett (2016) 26 : 2092 -2097
PubMed 26951751 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.73 7.08

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1096256 AGELASTATIN A 1 7.08
CHEMBL3787074 1 6.32
CHEMBL3785113 1 5.76
CHEMBL3786594 1 5.34
CHEMBL3298663 1 5.11
CHEMBL3786109 1 4.77
CHEMBL3787242 1 -
CHEMBL3785371 1 -
CHEMBL3786835 1 -
CHEMBL3787605 1 -
CHEMBL3786941 1 -
CHEMBL3785893 1 -
CHEMBL3787071 1 -
CHEMBL3787126 1 -
CHEMBL3787378 1 -
CHEMBL3786417 1 -
CHEMBL3785283 1 -
CHEMBL3298978 1 -
CHEMBL3786049 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1096256 AGELASTATIN A IC50 = 84.0 nM 7.08
CHEMBL3787074 IC50 = 479.0 nM 6.32
CHEMBL3785113 IC50 = 1720.0 nM 5.76
CHEMBL3786594 IC50 = 4530.0 nM 5.34
CHEMBL3298663 IC50 = 7850.0 nM 5.11
CHEMBL3786109 IC50 = 17000.0 nM 4.77
CHEMBL3787242 IC50 > 20000.0 nM -
CHEMBL3785371 IC50 > 20000.0 nM -
CHEMBL3786835 IC50 > 20000.0 nM -
CHEMBL3787605 IC50 > 20000.0 nM -
CHEMBL3786941 IC50 > 20000.0 nM -
CHEMBL3785893 IC50 > 20000.0 nM -
CHEMBL3787071 IC50 > 20000.0 nM -
CHEMBL3787126 IC50 > 20000.0 nM -
CHEMBL3787378 IC50 > 20000.0 nM -
CHEMBL3786417 IC50 > 20000.0 nM -
CHEMBL3785283 IC50 > 20000.0 nM -
CHEMBL3298978 IC50 > 20000.0 nM -
CHEMBL3786049 IC50 > 20000.0 nM -