Assay Detail
Binding
CHEMBL3789694
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Inhibition of insulin receptor (unknown origin) in presence of [gamma33P]ATP
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.43 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 7.47 |
| CHEMBL3786167 | — | — | 1 | 7.03 |
| CHEMBL3785951 | — | — | 1 | 6.76 |
| CHEMBL3785500 | — | — | 1 | 6.29 |
| CHEMBL3787614 | — | — | 1 | 6.03 |
| CHEMBL1614712 | — | — | 1 | 5.99 |
| CHEMBL3787112 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1091644 | LINSITINIB | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3786167 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL3785951 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL3785500 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL3787614 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL1614712 | — | IC50 | = | 1018.0 | nM | 5.99 |
| CHEMBL3787112 | — | IC50 | = | 3800.0 | nM | 5.42 |