Assay Detail
Binding
CHEMBL3789696
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length insulin receptor (unknown origin) transfected in Ba/F3 cells assessed as cell proliferation
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.94 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3786167 | — | — | 1 | 7.44 |
| CHEMBL3787614 | — | — | 1 | 7.19 |
| CHEMBL3785500 | — | — | 1 | 7.19 |
| CHEMBL3785951 | — | — | 1 | 7.03 |
| CHEMBL1091644 | LINSITINIB | 3.0 | 1 | 6.90 |
| CHEMBL1614712 | — | — | 1 | 6.61 |
| CHEMBL3787112 | — | — | 1 | 6.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3786167 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3787614 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3785500 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3785951 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL1614712 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL3787112 | — | IC50 | = | 638.0 | nM | 6.20 |