Assay Detail
Binding
CHEMBL3789758
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Inhibition of recombinant Vibrio cholerae alpha-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Vibrio cholerae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 7.23 | 9.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268439 | — | — | 1 | 9.23 |
| CHEMBL224292 | — | — | 1 | 8.38 |
| CHEMBL6633 | — | — | 1 | 8.33 |
| CHEMBL6753 | — | — | 1 | 7.92 |
| CHEMBL265674 | — | — | 1 | 7.63 |
| CHEMBL6784 | — | — | 1 | 7.52 |
| CHEMBL6919 | — | — | 1 | 7.37 |
| CHEMBL266240 | — | — | 1 | 7.34 |
| CHEMBL7146 | — | — | 1 | 7.28 |
| CHEMBL2324864 | — | — | 1 | 7.26 |
| CHEMBL269122 | — | — | 1 | 7.25 |
| CHEMBL414 | CARZENIDE | 2.0 | 1 | 7.22 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 7.20 |
| CHEMBL266026 | — | — | 1 | 7.15 |
| CHEMBL2324869 | — | — | 1 | 7.00 |
| CHEMBL2324868 | — | — | 1 | 6.90 |
| CHEMBL6724 | — | — | 1 | 6.88 |
| CHEMBL7092 | — | — | 1 | 6.86 |
| CHEMBL6853 | — | — | 1 | 6.70 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | 3.0 | 1 | 6.66 |
| CHEMBL7087 | — | — | 1 | 6.40 |
| CHEMBL6852 | — | — | 1 | 6.36 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 6.35 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268439 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL224292 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL6633 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL6753 | — | Ki | = | 12.1 | nM | 7.92 |
| CHEMBL265674 | — | Ki | = | 23.5 | nM | 7.63 |
| CHEMBL6784 | — | Ki | = | 30.3 | nM | 7.52 |
| CHEMBL6919 | — | Ki | = | 42.7 | nM | 7.37 |
| CHEMBL266240 | — | Ki | = | 45.3 | nM | 7.34 |
| CHEMBL7146 | — | Ki | = | 52.1 | nM | 7.28 |
| CHEMBL2324864 | — | Ki | = | 54.5 | nM | 7.26 |
| CHEMBL269122 | — | Ki | = | 56.7 | nM | 7.25 |
| CHEMBL414 | CARZENIDE | Ki | = | 59.8 | nM | 7.22 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 62.9 | nM | 7.20 |
| CHEMBL266026 | — | Ki | = | 71.5 | nM | 7.15 |
| CHEMBL2324869 | — | Ki | = | 99.1 | nM | 7.00 |
| CHEMBL2324868 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL6724 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL7092 | — | Ki | = | 139.0 | nM | 6.86 |
| CHEMBL6853 | — | Ki | = | 199.0 | nM | 6.70 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL7087 | — | Ki | = | 402.0 | nM | 6.40 |
| CHEMBL6852 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL419 | MAFENIDE | Ki | = | 447.0 | nM | 6.35 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 471.0 | nM | 6.33 |