Assay Detail
Binding
CHEMBL3789760
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Vibrio cholerae gamma-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Vibrio cholerae |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 6.56 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265674 | — | — | 1 | 7.18 |
| CHEMBL7087 | — | — | 1 | 7.16 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 7.16 |
| CHEMBL6753 | — | — | 1 | 7.16 |
| CHEMBL7146 | — | — | 1 | 7.13 |
| CHEMBL6853 | — | — | 1 | 7.13 |
| CHEMBL7092 | — | — | 1 | 7.13 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | 3.0 | 1 | 7.12 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 7.11 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 7.11 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 7.09 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 7.07 |
| CHEMBL218490 | DORZOLAMIDE | 4.0 | 1 | 7.06 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 7.06 |
| CHEMBL224292 | — | — | 1 | 7.05 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.04 |
| CHEMBL2324868 | — | — | 1 | 7.03 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 7.03 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 7.02 |
| CHEMBL6724 | — | — | 1 | 7.02 |
| CHEMBL266026 | — | — | 1 | 6.56 |
| CHEMBL328560 | SULTHIAME | 3.0 | 1 | 6.33 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.33 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.31 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | 4.0 | 1 | 6.30 |
| CHEMBL2324869 | — | — | 1 | 6.26 |
| CHEMBL310671 | SACCHARIN | 3.0 | 1 | 6.26 |
| CHEMBL6919 | — | — | 1 | 6.25 |
| CHEMBL266240 | — | — | 1 | 6.25 |
| CHEMBL6852 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265674 | — | Ki | = | 66.2 | nM | 7.18 |
| CHEMBL7087 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL6753 | — | Ki | = | 69.9 | nM | 7.16 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 68.8 | nM | 7.16 |
| CHEMBL7146 | — | Ki | = | 73.3 | nM | 7.13 |
| CHEMBL6853 | — | Ki | = | 73.6 | nM | 7.13 |
| CHEMBL7092 | — | Ki | = | 73.6 | nM | 7.13 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 76.3 | nM | 7.12 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 77.6 | nM | 7.11 |
| CHEMBL26 | SULPIRIDE | Ki | = | 77.9 | nM | 7.11 |
| CHEMBL419 | MAFENIDE | Ki | = | 80.6 | nM | 7.09 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 85.1 | nM | 7.07 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 87.3 | nM | 7.06 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 87.1 | nM | 7.06 |
| CHEMBL224292 | — | Ki | = | 88.5 | nM | 7.05 |
| CHEMBL77517 | INDISULAM | Ki | = | 91.3 | nM | 7.04 |
| CHEMBL2324868 | — | Ki | = | 93.6 | nM | 7.03 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 95.3 | nM | 7.02 |
| CHEMBL6724 | — | Ki | = | 95.3 | nM | 7.02 |
| CHEMBL266026 | — | Ki | = | 273.0 | nM | 6.56 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 473.0 | nM | 6.33 |
| CHEMBL328560 | SULTHIAME | Ki | = | 464.0 | nM | 6.33 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 494.0 | nM | 6.31 |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL2324869 | — | Ki | = | 544.0 | nM | 6.26 |
| CHEMBL310671 | SACCHARIN | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL6919 | — | Ki | = | 556.0 | nM | 6.25 |
| CHEMBL266240 | — | Ki | = | 563.0 | nM | 6.25 |
| CHEMBL6852 | — | Ki | = | 672.0 | nM | 6.17 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 725.0 | nM | 6.14 |
| CHEMBL2324864 | — | Ki | = | 764.0 | nM | 6.12 |
| CHEMBL865 | VALDECOXIB | Ki | = | 817.0 | nM | 6.09 |
| CHEMBL118 | CELECOXIB | Ki | = | 834.0 | nM | 6.08 |
| CHEMBL269122 | — | Ki | = | 902.0 | nM | 6.04 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 1230.0 | nM | 5.91 |
| CHEMBL6633 | — | Ki | = | 4153.0 | nM | 5.38 |
| CHEMBL414 | CARZENIDE | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL268439 | — | Ki | = | 5570.0 | nM | 5.25 |
| CHEMBL6784 | — | Ki | = | 6223.0 | nM | 5.21 |