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Assay Detail

CHEMBL3790100

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human thymidine kinase deficient 143B cells after 72 hrs by SRB assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type 143B
Confidence 1 — Organism
Curated By Autocuration

Target

143B (CHEMBL614508)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and anticancer activity of some 5-fluoro-2'-deoxyuridine phosphoramidates.
Lewandowska M, Ruszkowski P, Chojnacka K, Kleczewska N, Hoffmann M, Kacprzak K, Celewicz L.
Bioorg Med Chem (2016) 24 : 2330 -2341
PubMed 27073055 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.08 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3785877 1 5.70
CHEMBL3785172 1 5.60
CHEMBL3786607 1 5.51
CHEMBL3786773 1 5.44
CHEMBL3787574 1 5.41
CHEMBL3785842 1 5.06
CHEMBL3785362 1 5.04
CHEMBL3787087 1 4.90
CHEMBL3786992 1 4.88
CHEMBL917 FLOXURIDINE 4.0 1 4.85
CHEMBL3787373 1 4.80
CHEMBL185 FLUOROURACIL 4.0 1 4.79
CHEMBL803 CYTARABINE 4.0 1 4.77
CHEMBL3786911 1 4.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3785877 IC50 = 2010.0 nM 5.70
CHEMBL3785172 IC50 = 2510.0 nM 5.60
CHEMBL3786607 IC50 = 3070.0 nM 5.51
CHEMBL3786773 IC50 = 3620.0 nM 5.44
CHEMBL3787574 IC50 = 3900.0 nM 5.41
CHEMBL3785842 IC50 = 8670.0 nM 5.06
CHEMBL3785362 IC50 = 9110.0 nM 5.04
CHEMBL3787087 IC50 = 12720.0 nM 4.90
CHEMBL3786992 IC50 = 13100.0 nM 4.88
CHEMBL917 FLOXURIDINE IC50 = 14100.0 nM 4.85
CHEMBL3787373 IC50 = 16010.0 nM 4.80
CHEMBL185 FLUOROURACIL IC50 = 16310.0 nM 4.79
CHEMBL803 CYTARABINE IC50 = 16880.0 nM 4.77
CHEMBL3786911 IC50 = 47000.0 nM 4.33